Scancell cancer vaccines

rdrokit · **Reply #40 on:** February 10, 2018, 05:46:49 PM

Looks promising. Time will tell.

Roger · **Reply #41 on:** February 14, 2018, 04:05:34 AM

Yes RDRO - promising indeed and tick tock . . . . . . .
Here's more from CRUK about the 'Grand Challenge' :-

http://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/grand-challenge-award/shortlistedteamdurrant

Roger · **Reply #42 on:** February 15, 2018, 07:39:25 PM

Some words from little me in another place . .
If you have the time, watch the interview in this link.
You can buy shares at around 13 pence - who knows where the SP is going - ''in the near to short term''.

''Massive congratulations to our coming Nobel Prize winner, Prof. Durrant and a million pats on the back for Dr Goodfellow, who has farmed these fields with devotion and the greatest skill and persistence IMO. We all get a little bit older so a Happy Non Exec life to RG.

Dr Holloway looks to me, to be the right Guy to take SCLP forward now. An impressiive unprompted and clear performance from him. A long wait for us LTH, but following the growth of this incredible science, has been a rabbit chase. Tick tock . . . . . . .

http://www.proactiveinvestors.co.uk/companies/stocktube/8748/new-scancell-chief-sets-out-his-vision-to-commercialise-groundbreaking-cancer-treatments-8748.html

Roger · **Reply #43 on:** February 17, 2018, 05:43:38 AM

Daily news from Scancell atm. An extensive Presentation yesterday at Calculus Capital - Prof. Lindy Durrant and Prof. Poulam Patel. Some really interesting graphics - just for anyone interested.

https://www.scancell.co.uk/file-manager/PDFs/scancell-presentation-feb18v2.pdf

DYOR and GL.

rdrokit · **Reply #44 on:** March 01, 2018, 12:03:16 PM

Roger,
Just read this article. Looks promising.

https://www.nih.gov/news-events/nih-research-matters/injection-prompts-mouse-immune-system-destroy-tumors

Roger · **Reply #45 on:** March 01, 2018, 01:18:57 PM

Thanks RDRO. Yes very interesting for an early study.

Get a load of this from a recent Scancell presentation at the Royal Society of Medicine:-

https://m.youtube.com/watch?v=zogJ2CCmOxY

It's 28 well worthwhile minutes, but if you scroll through at 9 minutes, you'll see the lovely Prof. Lindy Durrant talking about the science. Fantastic Lady. Fantastic science.

ATB

rdrokit · **Reply #46 on:** March 01, 2018, 02:59:46 PM

Roger,
Very informative. I would think if they make a big breakthrough some big pharmaceutical company would buy them out.

Roger · **Reply #47 on:** March 02, 2018, 04:43:20 AM

RDRO the BB view is that Scancell are pursuing an 'Arm Holdings' strategy - licensing out the Intellectual Property to Pharma. (similar strategy to Arms H, recently sold for £23 billion).

An unedited version of the Presentation at Royal Society of medicine has become available.

https://www.youtube.com/watch?v=CXyPYib5JWc

Listen at 29 minutes 30 seconds, Prof. Lindy says, 'my aim is to cure all cancers'.

Amazing - IMO it looks like that might be on the way. 14 pence LOL.

Roger · **Reply #48 on:** October 02, 2018, 08:15:31 AM

A first for 'Immunotherapy' - the Nobel Prize has been awarded for the science behind 'checkpoint inhibitors' - it's been found that 'CI' can help up to 30% of Patients BUT at considerable cost and with sometimes awful side effects.

Scancell's 'Immunobody' vaccine in pre-clinical trial in combo with CI, achieved 90% efficacy. Scancell's SCIB1 combo trial shortly to start in the USA and the UK, will have an 'Investigator' in Allison's ''University of Texas MD Anderson Cancer Center''.

With my shares lumping around on 10.75 pence each - maybe the sentiment is about to change. From the Guardian:-

''James Allison and Tasuku Honjo will share the 9m Swedish kronor (£775,000) prize, announced by the Nobel assembly at the Karolinska Institute in Stockholm'' . . . . .

and . .

“Over the last decade, work from both these Nobel prize winners has led to the development in the clinic of a new class of therapies – so-called checkpoint inhibitor therapies – that are transforming the management of haematological and solid tumours,” he said. “A decade ago, metastatic melanoma was largely incurable. Thanks to work from Allison and Honjo, patients now have real hope, with over a third of patients deriving long-term benefit and even cures from such therapies.”

https://www.theguardian.com/science/2018/oct/01/james-p-allison-and-tasuku-honjo-win-nobel-prize-for-medicine

Roger · **Reply #49 on:** November 21, 2018, 07:17:35 AM

Dr Cliff Holloway - CEO of Scancell - presenting at a recent Investor Forum :-

https://www.youtube.com/watch?v=nKd_cDot6cw

Have a look at Page 7 - Modi-1 - 100% response.

I believe I am right in saying that Cancer Research UK is the largest cancer charity in the World - they have taken Scancell's SCIB2 for lung cancer into their development facilities. Also Scancell are one of 10 finalists for the CRUK's Grand Challenge - 21 of the top experts in the World in the presentation team. the prize - up to £20 million.

Current Share price is 9 pence, possible value £'s 1,3,5,9 - who knows ? Other Companies with a scrap of this science are valued at many Billions. Don't say I didn't tell you. ATB

dereklev · **Reply #50 on:** November 21, 2018, 07:49:58 AM

Quote from: Roger on November 21, 2018, 07:17:35 AM

Dr Cliff Holloway - CEO of Scancell - presenting at a recent Investor Forum :-

https://www.youtube.com/watch?v=nKd_cDot6cw

Have a look at Page 7 - Modi-1 - 100% response.

I believe I am right in saying that Cancer Research UK is the largest cancer charity in the World - they have taken Scancell's SCIB2 for lung cancer into their development facilities. Also Scancell are one of 10 finalists for the CRUK's Grand Challenge - 21 of the top experts in the World in the presentation team. the prize - up to £20 million.

Current Share price is 9 pence, possible value £'s 1,3,5,9 - who knows ? Other Companies with a scrap of this science are valued at many Billions. Don't say I didn't tell you. ATB

With the slow but steady flow of countries legalising medical marijuana there will be no need for a pharmaceutical cure,

Even Thailand has legalised its use.

Roger · **Reply #51 on:** November 21, 2018, 02:44:53 PM

Hello Derek, I don't think that marijuana has been identified as a possible cure for cancer.

Here's a bit more for you :-

https://www.youtube.com/watch?v=CXyPYib5JWc

Roger · **Reply #52 on:** November 22, 2018, 05:57:33 AM

Now, as for cannabis and cancer, I read quite a few links on Google and whilst there is some evidence that marijuana can slow progress of cancer cells, there's also some evidence it can speed them up. With the market for cancer immunotherapy due to reach £100 billion in the next few years, do you really think that Pharma would ignore marijuana as a potential cure if there was any credible evidence ?

I have seen several suggestions that marijuana can help with some cancer symptoms such as nausea, pain, food intake. Good.

The American Cancer Society comments here :-

https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/marijuana-and-cancer.html

Again - please post politely

dereklev · **Reply #53 on:** November 22, 2018, 06:16:10 AM

You made both these posts which is true!!!

Hello Derek, I don't think that marijuana has been identified as a possible cure for cancer.

Now, as for cannabis and cancer, I read quite a few links on Google and whilst there is some evidence that marijuana can slow progress of cancer cells, there's also some evidence it can speed them up. With the market for cancer immunotherapy due to reach £100 billion in the next few years, do you really think that Pharma would ignore marijuana as a potential cure if there was any credible evidence ?

Roger · **Reply #54 on:** November 22, 2018, 07:10:10 AM

Derek with respect - both are true.

There is a difference between a 'cure' for cancer and 'relief' from it's symptoms. Marijuana can help sometimes with relief from symptoms and one day, who knows ?

Re. the development of a cancer - ''marijuana can slow progress of cancer cells, there's also some evidence it can speed them up''.

https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/marijuana-and-cancer.html

And your opening comment, ''With the slow but steady flow of countries legalising medical marijuana there will be no need for a pharmaceutical cure''. Sorry that's just not true. The whole Pharma World is looking for a cure and have found checkpoint inhibitors and CAR-T therapies with cancer vaccines coming through.

dereklev · **Reply #55 on:** November 22, 2018, 07:26:26 AM

Quote from: Roger on November 22, 2018, 07:10:10 AM

Derek with respect - both are true.

There is a difference between a 'cure' for cancer and 'relief' from it's symptoms. Marijuana can help sometimes with relief from symptoms and one day, who knows ?

Re. the development of a cancer - ''marijuana can slow progress of cancer cells, there's also some evidence it can speed them up''.

https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/marijuana-and-cancer.html

And your opening comment, ''With the slow but steady flow of countries legalising medical marijuana there will be no need for a pharmaceutical cure''. Sorry that's just not true. The whole Pharma World is looking for a cure and have found checkpoint inhibitors and CAR-T therapies with cancer vaccines coming through.

Here is a link to a link about Big Pharma and Marijuana...

https://www.google.co.th/search?q=Big+Pharma+and+Marijuana&oq=Big+Pharma+and+Marijuana&aqs=chrome..69i57.20116j1j7&sourceid=chrome&ie=UTF-8

Roger · **Reply #56 on:** November 22, 2018, 07:46:00 AM

Sorry Derek. The first article in your link - Pfizer observe ''our work in this area was confined to the Lab, never tested in Patients and eventually discontinued''.

The next -''Most common problems that can be treated with cannabis include: Parkinson’s disease Post-Traumatic Stress Disorder (PTSD) Seizure disorders Mood disorders
Pain disorders Degenerative neurological disorders Multiple sclerosis''

No one else seems to be mentioning marijuana as a potential 'cure' for cancer. But 'm' might help relieve some symptoms.

dereklev · **Reply #57 on:** November 22, 2018, 08:30:52 AM

Quote from: Roger on November 22, 2018, 07:46:00 AM

Sorry Derek. The first article in your link - Pfizer observe ''our work in this area was confined to the Lab, never tested in Patients and eventually discontinued''.

The next -''Most common problems that can be treated with cannabis include: Parkinson’s disease Post-Traumatic Stress Disorder (PTSD) Seizure disorders Mood disorders
Pain disorders Degenerative neurological disorders Multiple sclerosis''

No one else seems to be mentioning marijuana as a potential 'cure' for cancer. But 'm' might help relieve some symptoms.

I'll bow to your vastly superior knowledge

Roger · **Reply #58 on:** November 22, 2018, 09:09:20 AM

Sorry Derek. Bowing ain't wot it's about. Just the facts I hope.

I'm not being 'know all' but I've been reading about this science for 7 years now ! And reading comments on the BB, sometimes more than a hundred a day.

I still don't understand the science which is WAY OUT

If you have time, watch Professor Lindy Durrant of Scancell - at 14mins 58 secs.

https://www.youtube.com/watch?v=CXyPYib5JWc

This is her team for the CRUK Grand Challenge award, potentially £20 million :-
Prof LG Durrant University of Nottingham, Scancell Ltd., Nottingham
Prof Sahin,TRON, Mainz BioNTech, Mainz
Prof Melief, University of Leiden ISA pharmaceuticals, Leiden
Prof Mellman, Genentech, South San Francisco
Prof Cerundulo, University of Oxford
Prof Balachandran, Memorial Sloan Kettering Cancer Center, New York
Icahn School of Medicine at Mount Sinai, New York
Prof de Vries, Radboud University, Nijmegen
Prof Platten, German Cancer Research Center, Mannheim Heidelberg University
Prof Rammense, Eberhard-Karls University Tuebingen
Dr Benham, University of Durham
Prof Ottensmeier, University of Southampton
Prof Jaeger, National Center for Tumor Diseases German Cancer Research Center, Heidelberg
Prof Pandurangan, La Jolla Institute for Allergy & Immunology
Prof Mehanna, University of Birmingham

CRUK have already taken the SCIB2 vaccine for a lung cancer trial.

Another trial for malignant melanoma will be underway soon - Chief Investigator, Prof Keith Flaherty, one of the USA's top cancer surgeons. The latest submission to the FDA was 2600 pages long !

Have a look at this rather wooden presentation from the CEO - however the slides on screen are amazing https://www.youtube.com/watch?v=nKd_cDot6cw

And the thread has been read 1761 times. Nice day to you ATB

Roger · **Reply #59 on:** December 08, 2018, 03:12:13 PM

Hopefully this IS of interest to one or two K-F's - (I see the thread has 2000 views or more). In a few years time, cancer treatment is going to be very different and hopefully, much more effective. This particular trail-blazing Company, Scancell, have engaged 'Trinity Delta' as Advisors and they have written an impressive report. Share price around 8 pence atm.

http://docs.wixstatic.com/ugd/07354c_b3b393d919ad412aabb576db17467d6a.pdf

The next news from Scancell is likely to be an Award from CRUK's 'Grand Challenge'.