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Covid-19

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Online Roger

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There's some interesting bits of research starting - about the possibility of administering a different vaccine in Gen 1 dose 2 - 'multiple vaccine options' :-

"Researchers in the United Kingdom have launched a study that will mix and match two COVID-19 vaccines in a bid to ease the daunting logistics of immunizing millions of people %u2014 and potentially boost immune responses in the process" and ". . . . . . . the team will take regular blood samples to measure levels of antibodies and immune cells called T cells that participants produce against the coronavirus. It will also monitor for safety concerns. T cells could be key to boosting immune response. RNA vaccines have generated powerful antibody responses to the SARS-CoV-2 coronavirus. But they have not proved to be as good as the AstraZeneca and Oxford vaccine at stimulating a class of T cells called CD8+ T cells, says Zhou Xing, an immunologist at McMaster University in Hamilton, Canada. These cells can strengthen an immune response by identifying and destroying cells infected with the virus." https://www.nature.com/articles/d41586-021-00315-5?

Worth a look . . . .
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Online Roger

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Vaccines intradermal, inhaled or by pill ??

"Coronavirus vaccines could eventually be administered in the form of a pill, Nadhim Zahawi has suggested. The vaccines minister said that injections may not be the sole option for receiving dosages in future but that ensuring a healthy capacity of supplies remained the priority for the Government. Speaking to Times Radio, Mr Zahawi said: "There are technologies with pills and others being developed around the world and we will continue to look at those. "But we're making sure the UK will always have the capability and capacity to manufacture the variant vaccines that will deal with any variant virus.”

Asked about a slowdown for first jabs when second jabs are rolled out, Mr Zahawi said: "We've got the capacity to do first and second jabs. The limiting factor is the supply of vaccines.” Receiving a vaccine jab via a pill could help alleviate supply issues that have hindered the rollout in some areas of the world including Europe. Last month, a British biotech breakthrough signalled the possibility of turning injected vaccines into tablets as clinical trials in monkeys showed the oral vaccine to be highly effective in immunising them from the virus. Sussex-based IoBio and California’s ImmunityBio are applying for regulatory approval to run tests in Britain as clinical trials of the pill began on Americans in January. Chief executive of iosBio, Wayne Channon, said: "With our capsule you wouldn’t need medical professionals to administer the vaccine, you could send this out on Amazon Prime and have everyone vaccinated by Saturday.”

Other experts have said that new ways of administering the vaccine are needed. Kate Bingham, the former chair of the UK vaccine taskforce, said the process needed to be sped up, suggesting that people should be allowed to self-administer pills, nasal sprays and patches. Speaking last month to BBC Radio 4’s Today Programme, Ms Bingham said: "We need to improve the vaccine formats because, frankly, two injections delivered by healthcare professionals is not a good way of delivering vaccines. "We need to get vaccine formats which are much more scalable and distributable, so, whether they are pills or patches or nose sprays, we need to find better ways of developing and delivering vaccines, and we'll do that in collaboration, just as we've been doing that over the last few months."


https://www.telegraph.co.uk/news/2021/02/07/vaccine-could-made-available-pill-form-minister-says/
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Online Roger

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In respect of border controls, 'better late than never' of course, but surely, because this action comes so late, it'd be better to have immediate and stronger measures rather than delayed and weaker measures?

"Up to 205,000 passengers from countries with confirmed new variant cases are expected to enter the UK before hotel quarantine is enforced, The Telegraph can disclose. Passenger data show that 22,000 Britons will enter from the 33 “red list” countries from which foreign travel is banned in the three weeks between Priti Patel, the Home Secretary, announcing the policy and the first hotels opening on Feb 15. A further 183,600 passengers will have entered the UK from 27 other countries where Brazilian or south African variant cases have been confirmed, including Spain which has imposed border restrictions with Portugal because of its close links with Brazil."

What happened to the earlier Govt. proposition at the height of the 1st wave, that the UK had so much virus activity that a bit more was irrelevant ? 30 flights arriving daily from the stricken USA alone, throughout, with no health controls on entry and for months, no masks on public transport.  >:(

* * * * *

And . . . . "It is understood the airlines have recommended a fast track channel at airports for those heading for quarantine hotels to enable passengers to be identified and avoid mingling while going through border controls. The Government is expected to foot the £55 million initial bill for the hotel accommodation before recouping the money from passengers. It is not clear how far officials will go in pursuing non-payers through the courts."

IF the Govt. haven't got secure exit and transit from LHR for quarantined PAX arranged already then heads should roll. Similarly, PAX for quarantine must pay a deposit preferably before departure but otherwise on arrival at LHR. If this DT report of these 2 aspects is true, the words 'p*ss up, organise and brewery' come to mind.

https://www.telegraph.co.uk/politics/2021/02/07/205000-passengers-countries-new-variant-could-arrive-uk-hotel/
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Online Roger

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Early reports from Israel - encouraging data. Even more encouraging, in Tel Aviv it looks like you can get a free beer when you get done !

Boris please note !   :)   :)

"The Pfizer vaccine is 85 per cent effective after a single dose, an Israeli study has found as the country's top scientists endorsed the UK approach of giving out the jabs up to 12 weeks apart. Researchers at Sheba Medical Centre gave one dose to 7,000 healthcare workers in January and found there was an 85 per cent reduction rate in Covid symptoms after 15-28 days, while overall infections - including asymptomatic cases - fell by 75 per cent.

Prof Arnon Afek, the deputy director general at Sheba, said the studies vindicated the UK's approach where there is a significant time delay between the first and second dose, as it shows that the first dose offers strong protection. "This ground-breaking research supports the British government’s decision to begin inoculating its citizens with a single dose of the vaccine," he said. Prof Eyal Leshem, Director of Sheba's Institute for Travel & Tropical Medicine added: "This is the first study assessing effectiveness of a single vaccine dose in real life conditions and shows early effectiveness, even before the second dose was administered
."

https://www.telegraph.co.uk/global-health/science-and-disease/coronavirus-news-covid-vaccine-lockdown-end-school-test-uk-cases/
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Online Roger

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A 'universal vaccine' ??

Sunday and Monday's 'Guardian' - trials 'very soon' or 'relatively soon' - sounds good to me.

"Scientists say clinical trials for ‘variant-proof’ vaccines could start very soon.

Scientists are developing a range of second-generation Covid vaccines aimed at expanding protection against the disease.
Candidates include one version that could provide immune defence against many different virus variants, while other researchers are investigating vaccines that would generate responses aimed specifically at blocking transmission of the disease.

Other projects include research into the creation of multiple vaccines that could each tackle different virus strains but would be administered as a single jab in a manner similar to annual flu jabs, which currently combine four vaccines against different strains of the influenza virus. At present, Covid vaccines are designed to stop infected people becoming seriously ill, to prevent hospitalisations and deaths. It is not known yet how effective they are at blocking viruses passing from person to another.

“There is no indication that any of the new virus variants that have appeared recently are causing more severe disease than the original virus,” said Professor Jonathan Ball, a virologist at Nottingham University. “However, there is evidence that some of these new variants may be better at infecting and therefore spreading in populations that have existing partial immunity following natural infection or vaccination.”

One possible solution is a vaccine – now under development by a team of scientists including Ball – that targets not just the spike protein on the surface of the Covid virus but also another part of the virus, called the N protein. “Hopefully this should result in much wider response from immune systems and so provide a much broader immunity to the virus,” Ball told the Observer. “And given what we know now about the emergence of Covid virus variants, that could help us strengthen protection against the disease,” he added.

The project, which also involves the immunology company Scancell and researchers at Nottingham Trent University, has reached a stage where manufacture of the new vaccine has begun.

Ball said it was hoped clinical trials of the vaccine could be launched very soon. “The plasmid that forms the basis of the vaccine has already been used in other medical treatments and is tolerated well in patients,” he added. “So we are hopeful that we can press ahead with clinical trials relatively soon
."

https://www.theguardian.com/society/2021/feb/21/scientists-say-clinical-trials-for-variant-proof-vaccines-could-start-very-soon
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Online Coolkorat

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I know you've been plugging away with the Scancell shares for some time Roger, but this could well be a good time to buy them. The spike in the share value suggests others see the same potential and even if they just climb to their previous highest value it would be a doubling of the current price.

Screenshot-2021-02-23-085436" border="0


Online Roger

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That's right CK but I'm already in up to my ears  ;) and have been for the last 10 years   8)

The share price is crazy low at 24 pence IMO - when Moditope was discovered, the shares went to 62 pence. NOW there's so much more and Moditope is ready to go into trials on 4 difficult cancers   :) 

Re. a "Universal Covid Vaccine" - "Scientists say clinical trials for ‘variant-proof’ vaccines could start very soon" - Prof. Jonathan Ball

Prof. Lindy Durrant of Scancell . . . "Lindy is Professor of Cancer Immunotherapy at the University of Nottingham and CSO of Scancell Ltd. She has developed a panel of mabs recognised tumour associated glycans and has pioneered an new antibody engineering technology which enhances the avidity of mabs, termed Avidimabs. This has been applied to the anti-glycan mabs resulting in direct killing mabs. She has developed two vaccine platforms ImmunoBodyTM and ModitopeTM which induce potent killer CD8 T cells and and cytotoxic CD4 T cells to post-translational modifications respectively. The first ImmunoBodyTM, SCIB1, has completed a phase I/II clinical trial in which 14/16 patients with melanoma have been disease free for five years. The first product from the ModitopeTM platform will enter the clinic this year. Lindy has over 150 peer reviewed publications and is also the inventor on 66 patents. She was award of the Waldenstrom prize for cancer Immunotherapy in 2019."

And not only for treatment of cancers but also, the prospect of a vaccine as a general preventative - (this Lady is not given to wild claims . . . .) - "We have identified a common process that occurs in most cancer that can be recognised by the immune system. This would allow us to design a vaccine to stimulate an immune response which would recognise and kill early cancerous cells. This may have to be boosted yearly as for seasonal flu vaccines. It could be given to people at high risk of cancer or to adults over 60 which are the most common age group for this disease."

https://www.nottingham.ac.uk/medicine/people/lindy.durrant
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Online Roger

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IF you can put up with John Oliver's assinine humour - this might be interesting . . .  ???

https://youtu.be/_v-U3K1sw9U
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Offline Wizard

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Greetings From Florida! I just had my Covid Vaccination yesterday and my follow-up shot is scheduled for 2 weeks. My wife is 50 and is
scheduled for her vaccination the first of March.  What is the status of returning to Thailand with the vaccination and no quarantine required?
Do you guys have the vaccination available in Korat? Florida is back to normal. Mask not required, schools open since September and restaurants
open at full levels basically everything is normal. Some cities, Democratic run,still have masks required and restaurants at 50% level, such as,,
Tampa where the Super Bowl was played, but Tampa is the exception and not the Rule here in Florida. Ready to return Home!


Online Roger

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Greetings to you too Wizard   :)   Last daily count for Florida was 7000 + new cases and 130 deaths - in total 1.9 million cases and 30,000 deaths. Personally I'd keep my mask on M8   :o

Thailand has less than 100 deaths in total and vaccines are starting to arrive in small quantities - so far just Sinovac 200K.

Regarding your returning to Thailand, tests and compulsory quarantine 14 days (in a wide choice of approved Hotels) and health insurance is required right now, so you can come back now if you accept that.

But as your wife will be CV-19 safe several weeks after the 2nd dose - say the end of April, you might choose to travel later .

The tourist industry in Th. collapsed in 2020 but IMO they'll try to start reopening in a few months time as Folks are able to prove a vaccination status - there's rumbles about that facilitating some opening up.

So it's 'wait and see' but there's sure to be comments here to help you as Thailand introduces some changes to the current strict regime on entry.

Stay safe and good luck !
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Offline Wizard

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Greetings to you too Wizard   :)   Last daily count for Florida was 7000 + new cases and 130 deaths - in total 1.9 million cases and 30,000 deaths. Personally I'd keep my mask on M8   :o

Thailand has less than 100 deaths in total and vaccines are starting to arrive in small quantities - so far just Sinovac 200K.

Regarding your returning to Thailand, tests and compulsory quarantine 14 days (in a wide choice of approved Hotels) and health insurance is required right now, so you can come back now if you accept that.

But as your wife will be CV-19 safe several weeks after the 2nd dose - say the end of April, you might choose to travel later .

The tourist industry in Th. collapsed in 2020 but IMO they'll try to start reopening in a few months time as Folks are able to prove a vaccination status - there's rumbles about that facilitating some opening up.

So it's 'wait and see' but there's sure to be comments here to help you as Thailand introduces some changes to the current strict regime on entry.

Stay safe and good luck !

Thanks Roger for the info!
The Covid Deaths in the USA have reached 500,000 but there is a reason so many senior deaths are so high and even my sisters death in May
was originally classified as a Covid Death but has been reclassified as Cancer. Medicare in the US covers seniors 65+ and will pay the hospitals
$37,000 final payment for a Covid Death and $15,000 for other deaths, ie, my sisters death for cancer, which she outlived by 9 months before
Covid was diagnosed. So the half million Covid Deaths will be revised in the future as Medicare Patients Deaths are reexamined and reclassified.
My sisters death was due to cancer and not covid. My wife just spoke with  a friend of hers at Joho SubDistrict Office and a Nurse and she said
the vaccinations are coming for all of the population in the very near future including you guys. So hopefully, that will happen as soon as the government can get there supplies delivered on a regular basis. I figure our return will be delayed until late Summer. Hang in there. There is a plan
to take care of everyone in the Kingdom!


Online Roger

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Hi Wizard - re. vaccines in Thailand - although I am very pro-vaccines generally, the risk here is tiny unless you live in Samut Sakhon or a few other areas, so I am not too worried. The death toll in Th. is 83 total in more than a year.  However, if the BioNTech/Pfizer or Oxford/Astra Zeneca was available to Falang, (at a reasonable price), I would get dosed simply to facilitate a UK visit.

Thanks for the info. from Joho - let's see how that progresses - (I tend to doubt that 140 million doses will be secured in Thailand in the very near future or even during 2021)   ::)

If you get vaccinated in the USA, maybe you will be able to return, without quarantine, in a few months time. ATB
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein


Online Roger

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 . ."CEPI has secured financial support from Australia, Austria, Belgium, the Bill & Melinda Gates Foundation, Canada, Denmark, the European Commission, Finland, Germany, Hungary, Italy, Japan, Kuwait, Lithuania, Luxembourg, Malaysia, Mexico, Netherlands, New Zealand, Norway, Panama, Saudi Arabia, Serbia, Singapore, Switzerland, United Kingdom, USAID, Ethiopia, The Republic of Korea, Indonesia, and Wellcome. Additionally, CEPI has also received support from private sector entities as well as public contributions through the UN Foundation COVID-19 Solidarity Response Fund."

" . . . .  scientists at the University of Nottingham in the UK are working alongside pharmaceutical company Scancell and Nottingham Trent University to test its COVID-19 vaccine candidate, SN14, which targets both the spike protein as well as the nucleocapsid, or N-protein. By targeting this additional viral structure, which is far less likely to mutate, the vaccine if found safe and effective could work to protect people against COVID-19 irrespective of any mutations to the spike protein and, in theory, could work across other coronaviruses."

https://cepi.net/news_cepi/going-universal-the-search-for-an-all-in-one-coronavirus-vaccine/

Another helpful read : https://www.nature.com/articles/d41586-021-00340-4
''If you can't explain it simply, you don't understand it well enough'' - Albert Einstein